This is getting really interesting! i cant help but to really hate her family and Chosei well apart from her sister :P . I now see why they run away.

For a first story, this isn't really too bad. It's actually pretty good to be honest and a lot better then some of the first stories that I've seen floating around FictionPress. I've been on this site for seven years, and I'm pretty established as an author but I know that I need improvement still.

If you need any help, feel free to e-mail or PM me. So far, the only kind advice I have is for you to add a little more description. Description sets a picture in the reader's head and the more you describe the better we as readers can envision your characters. Also, it makes it to where your story isn't mostly dialogue, though, at times you can't help that.

If you have the time or wish to, feel free to read some of my stories. It's nice to meet new authors here on FictionPress.

What next? We wanna know!

Siblings running away. Good for a prologue.
Don't get wrong but sometimes prologues seem to drive me nuts when a story becomes inviting. As some of them eventually become no-shows. Know what I mean?

Now this one I like the sound of. And if there are chapters after this, I hope we find more out about Shizuka & Anzu's predicament.

I think you have a good foundation for a nice manga, i read a lot of manga to be honest, probably over 200 chapters each month depending on if i find a new manga. And yours stood out to me it will be interesting to see where the two sisters go to, and if their parents do any thing about it and if so what that will be and what troubles this could cause.

Good luck.